The aim of this work was evaluated antifungal potential of extracts from Avicennia schaueriana Stapf & Leechm. (Avicenniaceae), Laguncularia racemosa (L.) Gaertn. (Combretaceae) and Rhizophora mangle L. (Rhizophoraceae) against yeasts and dermatophytes of clinical importance. The leaves and bark from Brazilian mangrove plants were collected, dried and submitted to successive extractions with methanol in order to obtain the organic extracts. Antifungal activity test of the crude extracts was performed by disk diffusion and minimum inhibition concentration (MIC) methods towards the following microorganisms: yeasts (Candida albicans, C. parakrusei, C. tropicalis, C. glabrata, C. parapsilosis, Trichosporon beigelii and T. pullulans) and dermatophytes (Microsporum gypseum, Trichophyton mentagrophytes and T. rubrum). The phytochemical profile of the Brazilian mangrove plant extracts showed absence for alkaloids and saponins. However, were detected the presence of flavonoids, tannins and terpenes and steroids. Tannins represented the principal group detected in the bark. The results for the antifungal activity by disk diffusion showed that extracts exhibit a weak activity against yeasts. Only leaf extract from L. racemosa was active against C. glabrata and T. pullulans and the bark extract from R. mangle was active against C. parakrusei, T. beigelii and T. pullulans. In contrast, dermatophytes were most sensitive, mainly T. rubrum followed by T. mentagrophytes and M. gypseum. Minimum inhibition concentration (MIC) was determined only for extracts from L. racemosa and R. mangle. The leaf extract from L. racemosa showed MIC values of 115 mg/ml for C. parakrusei; 7.13 mg/ml for T. beigelii and T. pullulans; 45 mg/ml for M. gypseum; 22.5 mg/ml for T. mentagrophytes and 5.62 mg/ml for T. rubrum and the bark extract from L. racemosa exhibited MIC of 1.40 mg/ml for T. rubrum. The bark extract from R. mangle presented MIC values of 230 mg/ml for C. parapsilosis and T. beigelii; 115 mg/ml for C. albicans, C. glabrata and C. parakrusei and 90 mg/ml for all dermatophytes tested.
| Autor: Michelle Rose de Oliveira Silva | Currículo Lattes |
| Co-autor: N. Buarque Gusmão | Currículo Lattes |
